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KMID : 0366219830180020207
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Korean Journal of Hematology
1983 Volume.18 No. 2 p.207 ~ p.215
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Microangiopathic Homolytic Anemia in Patients with Gastrointestinal Malignancy
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육동휘/Dong Whee Youk
최명규/김관형/김훈교/박종원/김춘추/이경식/Myoung Kyu Choi/Kwan Hyoung Kim/Hoon Kyo Kim/Chong Won Park/Choon Choo Kim/Kyung Shik Lee
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Abstract
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Microangiopathic hemolytic anemia is characterised by helmolytic anemia, usually with
thrombocytopenia, and presence of fragmented red cells in peripheral blood smears.
Microangiopathic hemolytic anemia and thrombocytopenia is well-described complication
of widely metastatic carcinoma. Two patients with metastatic adenocarcinoma of
stomach and one patient with adenocarcinoma of colon developed microangiopathic
hemolytic anemia and thrombocytopenia.
One patient underwent intensive plasmapheresis and had a clinical response. Serum
sialic acid level and MMADCC (monocyte mediated antibody dependent cytotoxicity) was
paralled by this response.
Two patient had a transient response after chemotherapy with 5-fluorouracil,
adriamycin, and mitoinycin. Speculation as to pathogenesis and appropriate therapy are
discussed.
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KEYWORD
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